Facilitating Standardization through Living Labs – The Example of Drug Counterfeiting

The increasing threat inherent to counterfeited drugs requires coordinated effort among multiple actors with diverging interests. Although multiple initiatives exist, no comprehensive and promising development and diffusion of a commonly applicable and interoperable solution has taken place so far. Agreeing on standards is an essential step on the road to a successful initiative on drug counterfeiting. To facilitate standardization, especially the initiation of a standardization process, we propose the concept of Living Labs as an innovative developing and testing environment serving multiple purposes. Testing solutions in real-life-contexts, aligning multiple interests and resulting in a pre-standard and a proof-of-concept are the advantages of this concept which facilitate the participation and coordinated action among a broad set of different stakeholders

The Association of Dorsiflexion Flexibility on Knee Kinematics and Kinetics during a Drop Vertical Jump in Healthy Female Athletes

Purpose While previous studies have examined the association between ankle dorsiflexion flexibility and deleterious landing postures, it is not currently known how landing kinetics are influenced by ankle dorsiflexion flexibility. The purpose of this study was to examine whether ankle dorsiflexion flexibility was associated with landing kinematics and kinetics that have been shown to increase the risk of anterior cruciate ligament (ACL) injury in female athletes. Methods Twenty-three female collegiate soccer players participated in a preseason screening that included the assessment of ankle dorsiflexion flexibility and lower-body kinematics and kinetics during a drop vertical jump task. Results The results demonstrated that females with less ankle dorsiflexion flexibility exhibited greater peak knee abduction moments (r = −.442), greater peak knee abduction angles (r = .355), and less peak knee flexion angles (r = .385) during landing. The range of dorsiflexion flexibility for the current study was between 9° and 23° (mean = 15.0°; SD 3.9°). Conclusion Dorsiflexion flexibility may serve as a useful clinical measure to predict poor landing postures and external forces that have been associated with increased knee injury risk. Rehabilitation specialists can provide interventions aimed at improving dorsiflexion flexibility in order to ameliorate the impact of this modifiable factor on deleterious landing kinematics and kinetics in female athletes

Hip External Rotator Strength Is Associated With Better Dynamic Control of the Lower Extremity During Landing Tasks

Hip external rotator strength is associated with better dynamic control of the lower extremity during landing tasks. J Strength Cond Res 30(1): 282–291, 2016—The purpose of this study was to determine the association between hip strength and lower extremity kinematics and kinetics during unanticipated single-leg landing and cutting tasks in collegiate female soccer players. Twenty-three National Collegiate Athletic Association division I female soccer players were recruited for strength testing and biomechanical analysis. Maximal isometric hip abduction and external rotation strength were measured using a hand-held dynamometer and expressed as muscle torque (force × femoral length) and normalized to body weight. Three-dimensional lower extremity kinematics and kinetics were assessed with motion analysis and force plates, and an inverse dynamics approach was used to calculate net internal joint moments that were normalized to body weight. Greater hip external rotator strength was significantly associated with greater peak hip external rotation moments (r = 0.47; p = 0.021), greater peak knee internal rotation moments (r = 0.41; p = 0.048), greater hip frontal plane excursion (r = 0.49; p = 0.017), and less knee transverse plane excursion (r = -0.56; p = 0.004) during unanticipated single-leg landing and cutting tasks. In addition, a statistical trend was detected between hip external rotator strength and peak hip frontal plane moments (r = 0.39; p = 0.06). The results suggest that females with greater hip external rotator strength demonstrate better dynamic control of the lower extremity during unanticipated single-leg landing and cutting tasks and provide further support for the link between hip strength and lower extremity landing mechanics

Managing the Process of Multi Channel Alignment - The Case of a Large Multinational Corporation

Companies which operate multiple marketing channels face the challenge of properly aligning channel strategies and operations. The case of a large multinational corporation is used to describe the complex and situated nature of multi channel strategies. The case context is used to introduce a framework and a reference process for achieving channel alignment in strategic business units. We build upon the model of strategic channel alignment – a modification of the strategic alignment model – in the development of two instruments which are applied for information gathering and structuring during processes of channel alignment. Exemplary findings from the case are presented. This study concentrates on the development and shaping of a strategy process and supporting instruments which facilitate channel alignment but also reflects on strategic channel alignment as socially accomplished and situated activity. The instruments can be used to gather rich information in a structured way and to gain the required level of understanding necessary to facilitate communication and collaboration between managers to ultimately achieve alignment

Inter-organizational Interoperability through integration of Multiagent, Web Service, and Semantic Web Technologies

This paper presents a software architecture for inter-organizational multiagent systems. The architecture integrates Web service technology into multiagent systems to overcome the technical interoperability problem of current multiagent systems in the fast growing service-oriented environments. We integrate Semantic Web technology to make multiagent systems semantically interoperable. We address the problem of interoperability regarding interfaces, messaging protocols, data exchanged, and security whilst considering a dynamic e-business environment. The proposed architecture enables service virtualization, secure service access across organizational boundaries, service-to-agent communication, and OWL reasoning within agents

Detecting transient gravitational waves in non-Gaussian noise with partially redundant analysis methods

There is a broad class of astrophysical sources that produce detectable, transient, gravitational waves. Some searches for transient gravitational waves are tailored to known features of these sources. Other searches make few assumptions about the sources. Typically events are observable with multiple search techniques. This work describes how to combine the results of searches that are not independent, treating each search as a classifier for a given event. This will be shown to improve the overall sensitivity to gravitational-wave events while directly addressing the problem of consistent interpretation of multiple trials.Comment: 11 pages, 5 figure

Likelihood-ratio ranking of gravitational-wave candidates in a non-Gaussian background

We describe a general approach to detection of transient gravitational-wave signals in the presence of non-Gaussian background noise. We prove that under quite general conditions, the ratio of the likelihood of observed data to contain a signal to the likelihood of it being a noise fluctuation provides optimal ranking for the candidate events found in an experiment. The likelihood-ratio ranking allows us to combine different kinds of data into a single analysis. We apply the general framework to the problem of unifying the results of independent experiments and the problem of accounting for non-Gaussian artifacts in the searches for gravitational waves from compact binary coalescence in LIGO data. We show analytically and confirm through simulations that in both cases the likelihood ratio statistic results in an improved analysis.Comment: 10 pages, 6 figure